A ISIS é uma agência internacional de espionagem, e crises globais não passam de oportunidades para que os altamente treinados agentes possam confundir, enfraquecer e enganar uns aos outros. No centro de tudo está o chefe de espionagem, Sterling Archer, que responde imediatamente à própria mãe, Malory Archer. Além dela, ele precisa lidar com a ex-namorada, Agente Lana Kane, e o novo namorado dela, o administrador Cyrill Figgis.
There’s not a whole lot of intelligence in the office of the ISIS, an international spy agency where the employees’ best efforts are geared toward undermining and betraying one another. Master spy Sterling Archer is a suave, confident secret-keeper at work but a mess when it comes to his personal affairs. He has a tenuous relationship with his ex, fellow agent Lana Kane, and he doesn’t get along with his mother, who happens to be his boss. ISIS comptroller Cyril Figgis is jealous of Sterling’s lifestyle despite the fact he’s now dating Lana. Later, after ISIS is disbanded and the agents temporarily run a drug cartel to help fund their retirements, they return to their espionage roots as agents of the CIA. After arriving in Los Angeles, they organize a detective agency.
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