Uma mulher (Mila Kunis), com uma vida aparentemente perfeita – bom casamento, filhos exemplares, ótimo emprego, etc – acaba ficando estressada além do ponto com as obrigações de sua vida. Cansada desse estado, ela se une a duas outras mulheres (Kathryn Hahn e Kristen Bell) que passam pelos mesmos problemas que ela para sair em uma jornada de libertação.
A woman with a seemingly perfect life – a great marriage, overachieving kids, beautiful home, stunning looks and still holding down a career. However she’s over-worked, over committed and exhausted to the point that she’s about to snap. Fed up, she joins forces with two other over-stressed moms and all go on a quest to liberate themselves from conventional responsibilities, going on a wild un-mom like binge of freedom, fun and self-indulgence – putting them on a collision course with PTA Queen Bee Gwendolyn and her clique of devoted perfect moms.